Type I protein S deficiency and skin necrosis.
نویسندگان
چکیده
منابع مشابه
Type I protein S deficiency and skin necrosis.
A kindred with Type I protein S deficiency is described in which the index case developed skin necrosis during induction of oral anticoagulant therapy for deep venous thrombosis. Two other family members with protein S deficiency have been detected, and demonstrate the clinical variability of this condition.
متن کاملMannhalter families Protein S deficiency type I : identification
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متن کاملSimilar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from families with mixed type I/III protein S deficiency.
BACKGROUND Protein S, which circulates in plasma in both free and bound forms, is an anticoagulant protein that stimulates activated protein C and tissue factor pathway inhibitor. Hereditary type I protein S deficiency (low total and low free protein S) is a well-established risk factor for venous thrombosis, whereas the thrombosis risk associated with type III deficiency (normal total and low ...
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The answers are a definite YES to (i, ii and iii) and a very clear NO to (iv). Regarding (v), for decades our obstetrician colleagues have been advising, that on which days and how frequently coitus is to be done, in the management of anovulatory infertility, with drugs like clomiphene. Moreover some sort of mental and physical relaxation/drugs before the act are also prescribed, with an advice...
متن کاملProtein S deficiency type I: identification of point mutations in 9 of 10 families.
We identified potentially causative mutations in the active protein S gene (PROS 1) by direct sequencing of PROS 1-specific polymerase chain reaction (PRC) products of all 15 exons, including exon-intron boundaries in 10 families with hereditary protein S deficiency type I. Seven different mutations were found in 9 of 10 families, including one frame shift mutation, a previously published splic...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 1990
ISSN: 0032-5473
DOI: 10.1136/pgmj.66.775.389